Description

n-(n-((9-Fluorenylmethoxy)Carbonyl)-3-Aminoprop-1-Yl)-n-(o-(4,4'-Dimethoxytrityl)-2-Oxyethyl)-n-(o-(3-Carboxylpropionyl)-2-Oxyethyl)Amine is a sophisticated, multifunctional building block designed for advanced oligonucleotide synthesis. This compound matters because it integrates key protective groups (Fmoc and DMT) and a reactive handle, enabling precise, automated solid-phase synthesis of complex nucleic acid analogs. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing next-generation therapeutics, including antisense oligonucleotides, siRNA, and aptamers, where high purity and reliable coupling efficiency are critical.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite precursor or modified monomer for the automated synthesis of DNA/RNA strands.
• Therapeutic Oligonucleotide Production: Enables the manufacture of antisense drugs, siRNA, and miRNA for targeted gene silencing therapies.
• Probe and Primer Synthesis: Used to create labeled or modified nucleic acid probes for diagnostic assays and research (e.g., FISH, PCR).
• Aptamer Development: Facilitates the synthesis of chemically modified aptamers with enhanced stability and binding affinity for diagnostic and therapeutic applications.
• Synthesis of Conjugated Oligonucleotides: The carboxylpropionyl moiety allows for the attachment of reporter molecules (e.g., fluorophores, biotin) or drug payloads.
• Research & Development: A vital reagent in academic and industrial R&D for exploring novel nucleic acid chemistries and backbone modifications.

Basic Information

Item	Details
Product Name	n-(n-((9-Fluorenylmethoxy)Carbonyl)-3-Aminoprop-1-Yl)-n-(o-(4,4'-Dimethoxytrityl)-2-Oxyethyl)-n-(o-(3-Carboxylpropionyl)-2-Oxyethyl)Amine
CAS No.	151265-16-6
Molecular Formula	C52H50N2O10
Molecular Weight	862.97 g/mol
Synonyms	Fmoc-DMT-Glyceryl-Linker-Amine; 5'-O-(4,4'-Dimethoxytrityl)-N2-(9-fluorenylmethoxycarbonyl)-3'-amino-2',3'-dideoxy-3'-aminoprop-1-yl nucleoside derivative; DMT-Fmoc Protected Amino Linker; Oligonucleotide Synthesis Trityl Amino Linker; Amino Modifier C7 DMT with Fmoc; Fmoc-DMT Aminoalkyl Phosphoramidite precursor; 151265-16-6; CAS 151265-16-6
EINECS	Contact for details

Quality Control

Our n-(n-((9-Fluorenylmethoxy)Carbonyl)-3-Aminoprop-1-Yl)-n-(o-(4,4'-Dimethoxytrityl)-2-Oxyethyl)-n-(o-(3-Carboxylpropionyl)-2-Oxyethyl)Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity essential for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with full traceability are provided. Production can adhere to GMP guidelines for therapeutic-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.