Description

6-Chloro-4-Cyclopropyl-1H-Quinazolin-2-One is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 150878-36-7. This compound is a critical building block in modern medicinal chemistry, valued for its role in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based drug candidates targeting various disease pathways.
• Oncology Research: Used in the development of small-molecule inhibitors for cancer therapy, leveraging the quinazolinone scaffold's affinity for kinase enzymes.
• Antiviral Agent Development: Serves as a core structure for creating compounds with potential activity against viral infections.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag in studying protein-ligand interactions and cellular processes.
• Agrochemical Research: Investigated as a starting material for developing new crop protection agents with specific modes of action.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and process development projects.

Basic Information

Product Name	6-Chloro-4-Cyclopropyl-1H-Quinazolin-2-One
CAS No.	150878-36-7
Molecular Formula	C11H9ClN2O
Molecular Weight	220.65 g/mol
Synonyms	6-Chloro-4-cyclopropyl-2(1H)-quinazolinone; 4-Cyclopropyl-6-chloro-1H-quinazolin-2-one; 6-Chloro-4-cyclopropylquinazolin-2(1H)-one; 150878-36-7; 2(1H)-Quinazolinone, 6-chloro-4-cyclopropyl-; 6-Chloro-4-cyclopropyl-1,2-dihydroquinazolin-2-one; 6-Chloro-4-cyclopropyl-2-hydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Cyclopropyl-1H-Quinazolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.