Description

2-[3-(R)-[3-(2-(7-Chloro-2-Quinolinyl)Ethenyl)Phenyl]-3-Hydroxypropyl]Benzoic Acid Methyl Ester is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly leukotriene receptor antagonists. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of leukotriene receptor antagonist drug candidates and related anti-inflammatory agents.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile chiral scaffold for structure-activity relationship (SAR) studies and the discovery of new therapeutic entities.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: A starting material for the tailored synthesis of specialized derivatives and analogs for biological screening.

Basic Information

Item	Details
Product Name	2-[3-(R)-[3-(2-(7-Chloro-2-Quinolinyl)Ethenyl)Phenyl]-3-Hydroxypropyl]Benzoic Acid Methyl Ester
CAS No.	150026-72-5
Molecular Formula	C28H24ClNO3
Molecular Weight	457.95 g/mol
Synonyms	Montelukast Methyl Ester; (R)-Montelukast Methyl Ester; Methyl (R)-2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl]-3-hydroxypropyl]thio]methyl]cyclopropylacetate (related); 2-[3-(R)-[3-(2-(7-Chloro-2-quinolyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic acid methyl ester; MK-0476 Methyl Ester; SQ-476 Methyl Ester; (R)-2-[3-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-[3-(R)-[3-(2-(7-Chloro-2-Quinolinyl)Ethenyl)Phenyl]-3-Hydroxypropyl]Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.