Description

2-Chloro-5-Fluoro-4-Nitrobenzoic Acid is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique halogenated nitrobenzoic acid structure makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing halogenated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its nitro and halogen substituents.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the development of complex colorants and functional dyes due to its nitrobenzoic acid core.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Nitrobenzoic Acid
CAS No.	149903-77-5
Molecular Formula	C7H3ClFNO4
Molecular Weight	219.56 g/mol
Synonyms	4-Nitro-2-chloro-5-fluorobenzoic Acid; 2-Chloro-5-fluoro-4-nitrobenzoic acid; Benzoic acid, 2-chloro-5-fluoro-4-nitro-; 5-Fluoro-2-chloro-4-nitrobenzoic Acid; 2-Chloro-5-fluoronitrobenzoic Acid; 4-Nitro-5-fluoro-2-chlorobenzoic Acid; 149903-77-5; 2-Chloro-5-fluoro-4-nitro-benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluoro-4-Nitrobenzoic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.