Description

α-D-Ribofuranose,2-Deoxy-2-Fluoro-(9Ci) is a fluorinated carbohydrate derivative, specifically a 2-deoxy-2-fluoro ribofuranose, which serves as a critical synthetic intermediate and building block in medicinal chemistry. This compound is valued for its role in modifying nucleoside structures, imparting metabolic stability and altering biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapeutics, and diagnostic probes, particularly for PET imaging applications.

Application

• Nucleoside/Nucleotide Analog Synthesis: A key precursor for the development of fluorinated antiviral and anticancer drugs, such as modified nucleoside reverse transcriptase inhibitors.
• PET (Positron Emission Tomography) Tracer Development: Used in the radiosynthesis of [18F]-labeled probes for metabolic imaging and oncology research.
• Glycobiology & Glycochemistry Research: Acts as a stable glycosyl donor or acceptor in the synthesis of fluorinated oligosaccharides to study enzyme mechanisms and carbohydrate-protein interactions.
• Enzyme Inhibitor Design: Serves as a mechanism-based inhibitor for glycosidases and glycosyltransferases due to the fluorine atom's mimicry of the transition state.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of complex bioactive molecules where a fluorinated sugar moiety is required for optimal pharmacokinetics.
• Chemical Biology Probes: Incorporated into molecular probes to investigate cellular processes involving carbohydrate metabolism and recognition.

Basic Information

Product Name	α-D-Ribofuranose,2-Deoxy-2-Fluoro-(9Ci)
CAS No.	149624-22-6
Molecular Formula	C5H9FO4
Molecular Weight	152.12 g/mol
Synonyms	2-Deoxy-2-fluoro-D-ribofuranose; 2-Fluoro-2-deoxy-D-ribofuranose; 2-Deoxy-2-fluoro-α-D-ribofuranose; 2-Fluoro-2-deoxy-α-D-erythro-pentofuranose; 2-Fluoro-2-deoxy-D-erythro-pentofuranose; 2-Fluoro-2-deoxy-α-D-ribose; 2-Fluoro-2-deoxy-D-ribose; α-2-Fluoro-2-deoxyribofuranose
EINECS	Contact for details

Quality Control

Our α-D-Ribofuranose,2-Deoxy-2-Fluoro-(9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.