Description

3-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide is a high-purity, advanced chemical intermediate of significant interest in research and development. This compound is crucial for toxicological and metabolic studies, particularly in understanding the mechanisms of polycyclic aromatic hydrocarbon (PAH) activation and DNA adduct formation. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers focused on environmental carcinogenesis and metabolic pathway analysis.

Application

• Biochemical Research: Used as a standard or reference compound in studies investigating the metabolic activation pathways of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs).
• Toxicology & Carcinogenesis Studies: Serves as a critical reagent for in vitro and in vivo research on DNA damage, mutagenicity, and the carcinogenic potential of specific PAH derivatives.
• Analytical Chemistry: Employed as a high-purity analytical standard for method development and calibration in techniques like HPLC, LC-MS, and GC-MS for detecting and quantifying PAH metabolites.
• Environmental Science: Applied in research to model and understand the environmental fate, transformation, and biological impact of nitrated combustion by-products.
• Pharmaceutical Development: Utilized in early-stage discovery to study drug metabolism interactions and the bioactivation mechanisms of complex organic molecules.

Basic Information

Product Name	3-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide
CAS No.	149559-16-0
Molecular Formula	C20H11NO5
Molecular Weight	345.31 g/mol
Synonyms	3-Nitrobenzo[a]pyrene 7,8-diol 9,10-epoxide; 3-Nitro-BPDE; 3-Nitrobenzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; (±)-3-Nitrobenzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; 3-Nitro-B[a]PDE; 3-Nitro-B[a]P-7,8-diol-9,10-epoxide; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-3-nitrobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our 3-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, Acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.