Description

3-(tert-Butoxycarbonyl)-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepine-7-Carboxylic Acid is a high-purity, protected heterocyclic carboxylic acid building block essential for advanced organic synthesis. This compound is a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile scaffold for further functionalization. It is primarily utilized by research and development laboratories, pharmaceutical manufacturers, and specialty chemical producers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex benzazepine-based drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Synthesis: Used in the construction of conformationally constrained peptide analogs due to its rigid benzazepine core and protected amine functionality.
• Custom Synthesis & Contract Manufacturing: An important building block for custom synthesis services and the production of high-value, non-commercial specialty chemicals.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for biochemical and pharmacological research.

Basic Information

Product Name	3-(tert-Butoxycarbonyl)-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepine-7-Carboxylic Acid
CAS No.	149353-73-1
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	Boc-7-carboxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 7-Carboxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylic acid 1,1-dimethylethyl ester; 3-Boc-7-carboxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine; 1,1-Dimethylethyl 7-carboxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-carboxylate; tert-Butyl 7-carboxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine-3(2H)-carboxylate; 3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carboxylic acid; 149353-73-1
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butoxycarbonyl)-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepine-7-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.