Description

Tri-tert-Butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetate Hydrobromide is a high-purity, protected intermediate crucial for the synthesis of advanced macrocyclic chelating agents. This compound matters because it serves as a key precursor for creating functionalized DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivatives, which are essential in diagnostic and therapeutic applications. Pharmaceutical researchers, radiopharmaceutical developers, and advanced material scientists need this specialized building block to produce targeted contrast agents for medical imaging and novel metal complexes for research.

Application

• Radiopharmaceutical Precursor: A critical intermediate in the synthesis of DOTA-based chelators for labeling with radioisotopes like Gallium-68, Lutetium-177, and Yttrium-90 for targeted cancer therapy (theranostics) and PET/SPECT imaging.
• MRI Contrast Agent Development: Used to create next-generation gadolinium-based contrast agents with improved stability and targeting capabilities for magnetic resonance imaging.
• Research Chemical: Serves as a versatile scaffold in academic and industrial research for studying metal-ligand interactions, developing new sensors, and creating novel macrocyclic complexes.
• Peptide & Antibody Conjugation: The protected acetate groups and reactive amine allow for site-specific conjugation to peptides, antibodies, or other biomolecules to create targeted diagnostic and therapeutic probes.
• Catalyst Ligand Synthesis: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis and asymmetric synthesis.

Basic Information

Item	Details
Product Name	Tri-tert-Butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetate Hydrobromide
CAS No.	149353-23-1
Molecular Formula	C30H57BrN4O6
Molecular Weight	649.70 g/mol
Synonyms	DOTA-tris(t-Bu ester) hydrobromide; 1,4,7-Tris(carboxy-tert-butoxymethyl)-1,4,7,10-tetraazacyclododecane hydrobromide; 1,4,7-Tris[(tert-butoxycarbonyl)methyl]-1,4,7,10-tetraazacyclododecane HBr; Tri-tert-butyl DOTA hydrobromide; DOTA-tris(t-butyl ester) HBr salt; 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane hydrobromide; Protected DOTA-tris ester HBr; Macrocyclic intermediate 149353-23-1
EINECS	Contact for details

Quality Control

Our Tri-tert-Butyl DOTA-tris(t-Bu ester) HBr is manufactured under strict quality management systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.