Description

n-Acetyl-8-o-(n-Acetyl-A-Neuraminyl)-Neuraminic Acid Disodium Salt is a chemically defined, high-purity derivative of sialic acid, a critical carbohydrate component in glycobiology. This compound is essential for advanced research and development in the life sciences, serving as a key intermediate and reference standard. It is primarily utilized by biopharmaceutical companies, diagnostic manufacturers, and academic research institutions focused on glycoscience, vaccine development, and therapeutic protein characterization.

Application

• Biopharmaceutical Research: As a critical intermediate in the synthesis of complex glycoconjugates for novel therapeutics and vaccines.
• Diagnostic Reagent Manufacturing: Used in the production of high-sensitivity assay kits for detecting sialic acid-related biomarkers.
• Enzymology Studies: Serves as a specific substrate or inhibitor for sialidases (neuraminidases) and sialyltransferases in kinetic studies.
• Glycoprotein Analysis: Acts as a reference standard in analytical techniques like HPLC and MS for characterizing glycosylation patterns of therapeutic proteins.
• Cell Biology & Immunology: Used to study cell surface interactions, receptor binding, and immune modulation mediated by sialylated structures.
• Academic & Institutional Research: A key reagent for fundamental research in carbohydrate chemistry and glycolbiology pathways.

Basic Information

Product Name	n-Acetyl-8-o-(n-Acetyl-A-Neuraminyl)-Neuraminic Acid Disodium Salt
CAS No.	149331-75-9
Molecular Formula	C23H35N3Na2O17
Molecular Weight	671.51 g/mol
Synonyms	Disialic Acid Disodium Salt; α-2,8-Linked Disialic Acid Disodium Salt; 8-O-(N-Acetyl-α-neuraminosyl)-N-acetylneuraminic Acid Disodium Salt; Neu5Acα2-8Neu5Ac Disodium Salt; Di-N-acetylneuraminic Acid Disodium Salt (α2,8-linked); Colominic Acid Disodium Salt (specific fraction); GD3 Disialic Acid Analog Disodium Salt; 149331-75-9
EINECS	Contact for details

Quality Control

Our n-Acetyl-8-o-(n-Acetyl-A-Neuraminyl)-Neuraminic Acid Disodium Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including NMR, HPLC, and MS to confirm identity, purity, and structural integrity. We provide Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.