Description

Hydroxy-Peg2-Ch2Co2T-Bu is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a terminal tert-butyl ester and a hydroxyl group, serving as a versatile building block for bioconjugation and linker chemistry. Its value lies in providing a hydrophilic spacer arm that enhances solubility and reduces steric hindrance in the synthesis of complex molecules like antibody-drug conjugates (ADCs) and peptide therapeutics. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, functionalized linkers for drug delivery systems and polymer synthesis.

Application

• As a key spacer/linker molecule in the design and synthesis of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics.
• For the functionalization of peptides and proteins to improve pharmacokinetic properties such as solubility and circulation half-life.
• In the development of PEGylated drug delivery systems, including nanoparticles and liposomes, for enhanced stability and targeted release.
• As a bifunctional monomer in the synthesis of specialized polymers and hydrogels for biomedical applications.
• For the surface modification of biomaterials and diagnostic agents to impart biocompatibility and stealth properties.
• In proteomics research as a tool for crosslinking, labeling, or immobilizing biomolecules.

Basic Information

Product Name	Hydroxy-Peg2-Ch2Co2T-Bu
CAS No.	149299-82-1
Molecular Formula	C13H26O6
Molecular Weight	278.34 g/mol
Synonyms	2-[2-(2-Hydroxyethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate; HO-PEG2-CH2COOtBu; 2,5,8-Trioxaundecan-11-oic acid, 11-tert-butyl ester; 11-(tert-Butoxy)-2,5,8-trioxaundecan-11-ol; PEG2 tert-butyl ester; Ethylene glycol oligomer derivative
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg2-Ch2Co2T-Bu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant cGMP guidelines for advanced intermediates and support our clients' regulatory filings with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), please contact us.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.