Description

6-Iodo-2-Trifluoromethylphenol is a versatile halogenated phenol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both iodine and a trifluoromethyl group on the aromatic ring, makes it a valuable intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl and iodo groups can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in the preparation of complex ligands for transition metal catalysis and organocatalysts due to its electron-withdrawing substituents.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution in aromatic systems and for synthesizing fluorinated analogs of bioactive compounds.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.

Basic Information

Item	Details
Product Name	6-Iodo-2-Trifluoromethylphenol
CAS No.	149209-48-3
Molecular Formula	C7H4F3IO
Molecular Weight	287.01 g/mol
Synonyms	2-Hydroxy-3-iodobenzotrifluoride; 3-Iodo-2-hydroxybenzotrifluoride; 2-Trifluoromethyl-6-iodophenol; 6-Iodo-2-(trifluoromethyl)phenol; Phenol, 6-iodo-2-(trifluoromethyl)-; 2-Hydroxy-3-iodo-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 6-Iodo-2-Trifluoromethylphenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.