Description

(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl-2-Propenal is a high-purity, advanced pharmaceutical intermediate characterized by its specific quinoline-based molecular architecture. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and anti-inflammatory pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of proprietary drug candidates and investigational new chemical entities.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic compounds and studying structure-activity relationships (SAR).
• API Development: Serves as a precursor in the production of active pharmaceutical ingredients, especially for neurological and anti-inflammatory applications.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Material Science Research: Investigated for potential use in the development of organic electronic materials due to its conjugated system.

Basic Information

Product Name	(E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl-2-Propenal
CAS No.	148901-68-2
Molecular Formula	C21H16FNO
Molecular Weight	317.36 g/mol
Synonyms	(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde; 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolineacrolein; (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]acrylaldehyde; 3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)prop-2-enal; 148901-68-2; Quinoline derivative CAS 148901-68-2; Fluorophenyl cyclopropyl quinoline propenal
EINECS	Contact for details

Quality Control

Every batch of (E)-3-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl-2-Propenal is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our rigorous quality testing ensures compliance with industry standards for advanced intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.