Description

Bicyclo[1.1.1]pentan-1-amine hydrochloride is a high-value, strained bicyclic building block of significant interest in modern organic and medicinal chemistry. Its unique [1.1.1]propellane-derived structure serves as a bioisostere for a para-substituted benzene ring or an alkyne, enabling the synthesis of novel compounds with improved physicochemical properties. This versatile intermediate is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for lead optimization and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in fragment-based drug discovery and for creating three-dimensional saturated bioisosteres.
• Agrochemical Research: Used in the development of new pesticides and herbicides where its rigid, lipophilic structure can enhance bioavailability and metabolic stability.
• Material Science: Serves as a precursor for advanced polymers and functional materials with unique mechanical or optical properties derived from the strained bicyclic core.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or spacer component due to its defined length and rigidity, which is crucial for ternary complex formation.
• Academic & R&D Synthesis: A valuable reagent for methodological development in organic synthesis, exploring new C-N bond formation and strain-release chemistry.

Basic Information

Product Name	Bicyclo[1.1.1]pentan-1-amine hydrochloride
CAS No.	148749-92-2
Molecular Formula	C5H10ClN
Molecular Weight	119.59 g/mol
Synonyms	1-Aminobicyclo[1.1.1]pentane hydrochloride; [1.1.1]Propellane-1-amine hydrochloride; BCP-amine HCl; Bicyclo[1.1.1]pentan-1-amine HCl; 1-Azabicyclo[1.1.1]pentane hydrochloride (common misnomer); 1-BCP-amine hydrochloride; (Bicyclo[1.1.1]pentan-1-yl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentan-1-amine hydrochloride is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support development from research to commercial scale, ensuring reliable supply of this critical building block.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture uptake and decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.