Description

(2S,3S)-3-[[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy]-2-Phenylpiperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its chiral piperidine core and trifluoromethylphenyl ether functionality. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery programs targeting central nervous system (CNS) disorders and other complex disease areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block in the synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and unique chemical scaffold.
• Process Chemistry Development: Employed in the scale-up and route development for the production of active pharmaceutical ingredients (APIs) under GMP conditions.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Tool Compound: Applied in preclinical research to investigate specific biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	(2S,3S)-3-[[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy]-2-Phenylpiperidine Hydrochloride
CAS No.	148700-85-0
Molecular Formula	C20H18F6NO•HCl
Molecular Weight	453.82 g/mol
Synonyms	(2S,3S)-3-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride; (2S,3S)-3-((3,5-Bis(trifluoromethyl)benzyl)oxy)-2-phenylpiperidine hydrochloride; 2-Phenyl-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]piperidine hydrochloride (2S,3S)-; L-703,606 oxalate salt precursor; cis-3-((3,5-Bis(trifluoromethyl)benzyl)oxy)-2-phenylpiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,3S)-3-[[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy]-2-Phenylpiperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.