Description

Bicyclo[1.1.1]pentane-1,3-diamine dihydrochloride is a high-value, strained bicyclic building block of significant interest in modern organic synthesis and medicinal chemistry. Its unique three-dimensional, rigid scaffold is prized for its ability to impart favorable physicochemical properties to molecules, making it a critical intermediate for advanced research and development. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to innovate with novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for creating bioisosteres to improve metabolic stability, solubility, and potency.
• Agrochemical Research: Used in developing new generation crop protection agents and herbicides that leverage its unique spatial geometry for enhanced target binding.
• Ligand and Catalyst Design: Employed in organometallic chemistry to construct chelating ligands and catalysts with precise, rigid geometries for asymmetric synthesis.
• Polymer and Material Science: Acts as a cross-linking agent or monomer for producing high-performance polymers with tailored thermal and mechanical properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Incorporated as a linker or core structure in bifunctional molecules designed for targeted protein degradation.
• Academic & Industrial R&D: A fundamental reagent for exploring new chemical space and structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1,3-diamine dihydrochloride
CAS No.	147927-61-5
Molecular Formula	C5H12N2 • 2HCl
Molecular Weight	197.09 g/mol
Synonyms	1,3-Diaminobicyclo[1.1.1]pentane dihydrochloride; Bicyclo[1.1.1]pentane-1,3-diamine hydrochloride (1:2); [1.1.1]Propellane-1,3-diamine dihydrochloride; BCP-diamine•2HCl; 1,3-BCP-diamine dihydrochloride
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1,3-diamine dihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent batch-to-batch reliability. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.