Description

5-Bromo-1,3-difluoro-2-nitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique combination of bromine, fluorine, and nitro substituents on the aromatic ring makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores with electron-withdrawing groups.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro and nitro groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira), enabling rapid diversification of the benzene scaffold.
• Nucleophilic Aromatic Substitution: The ortho- and para-fluorine atoms relative to the nitro group are highly activated for substitution with various nucleophiles, facilitating further functionalization.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex halogenated dyes and organic pigments due to its stable aromatic structure.

Basic Information

Product Name	5-Bromo-1,3-difluoro-2-nitrobenzene
CAS No.	147808-42-2
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-3,5-difluoro-2-nitrobenzene; 2-Nitro-1,3-difluoro-5-bromobenzene; 3,5-Difluoro-2-nitro-1-bromobenzene; 5-Bromo-2-nitro-1,3-difluorobenzene; Benzene, 1-bromo-3,5-difluoro-2-nitro-; 147808-42-2 (CAS); 5-Br-1,3-F2-2-NO2-Bz
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,3-difluoro-2-nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.