Description

4-Iodo-2,6-Difluoronitrobenzene is a high-value, multi-functional halogenated aromatic building block, distinguished by its unique combination of iodine, fluorine, and nitro substituents. This compound is critical for advanced organic synthesis, enabling precise molecular construction in demanding research and development environments. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials scientists for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or as a handle for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and iodo groups contribute to metabolic stability and binding affinity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis, leveraging the reactivity of the iodine atom.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and dyes, where the electron-withdrawing nitro and fluoro groups tune electronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions to form biaryl and other conjugated structures.
• Nucleophilic Aromatic Substitution: The ortho-fluorine atoms adjacent to the nitro group are highly activated for substitution with various nucleophiles, enabling diverse derivative synthesis.

Basic Information

Product Name	4-Iodo-2,6-Difluoronitrobenzene
CAS No.	147808-40-0
Molecular Formula	C6H2F2INO2
Molecular Weight	284.99 g/mol
Synonyms	1-Iodo-3,5-difluoro-4-nitrobenzene; 2,6-Difluoro-4-iodonitrobenzene; Benzene, 1-iodo-3,5-difluoro-4-nitro-; 3,5-Difluoro-4-iodonitrobenzene; 4-Nitro-2,6-difluoroiodobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-2,6-Difluoronitrobenzene is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.