Description

7-Chloro-3-Nitro-3,4-Dihydro-1H-Quinolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific quinolinone core structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, infectious diseases, or oncology.
• Agrochemical Research: Serves as a foundational scaffold for developing new herbicides, fungicides, or insecticides with specific modes of action.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing nitrogen-containing heterocyclic compounds due to its reactive chloro and nitro functional groups.
• Material Science Research: Investigated for potential use in creating organic electronic materials or specialty polymers with unique optical properties.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up production.

Basic Information

Product Name	7-Chloro-3-Nitro-3,4-Dihydro-1H-Quinolin-2-One
CAS No.	147778-05-0
Molecular Formula	C9H5ClN2O3
Molecular Weight	224.60 g/mol
Synonyms	7-Chloro-3-nitro-1,2,3,4-tetrahydroquinolin-2-one; 2H-Quinolin-2-one, 7-chloro-3,4-dihydro-3-nitro-; 7-Chloro-3-nitro-3,4-dihydro-2(1H)-quinolinone; 3-Nitro-7-chloro-3,4-dihydro-1H-quinolin-2-one; 147778-05-0; Quinolin-2-one, 7-chloro-3,4-dihydro-3-nitro-
EINECS	Contact for details

Quality Control

Our 7-Chloro-3-Nitro-3,4-Dihydro-1H-Quinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.