Description

Methyl-2-Amino-3-Cyclohexyl-3-Oxo-Propionate Hydrochloride is a high-purity, pharmaceutically relevant intermediate characterized by its specific chiral center and functional groups. This compound is critical for the synthesis of complex molecules, offering a key building block for advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and fine chemical manufacturers engaged in the production of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides with specific stereochemical requirements.
• Peptidomimetics Research: Used in the design and synthesis of peptide analogs and conformationally restricted scaffolds for biological evaluation.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in the development of stereoselective synthetic methodologies.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring novel organic transformations and medicinal chemistry.

Basic Information

Product Name	Methyl-2-Amino-3-Cyclohexyl-3-Oxo-Propionate Hydrochloride
CAS No.	147745-20-8
Molecular Formula	C11H20ClNO3
Molecular Weight	249.73 g/mol
Synonyms	Methyl 2-amino-3-cyclohexyl-3-oxopropanoate hydrochloride; 2-Amino-3-cyclohexyl-3-oxo-propionic acid methyl ester hydrochloride; Methyl 2-aminocyclohexylglyoxylate hydrochloride; (2R/S)-Methyl 2-amino-3-cyclohexyl-3-oxopropanoate hydrochloride; Cyclohexylglyoxylic acid, 2-amino-, methyl ester, hydrochloride; Methyl α-amino-β-cyclohexyl-β-oxopropionate HCl; 3-Cyclohexyl-3-oxo-2-aminopropionic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl-2-Amino-3-Cyclohexyl-3-Oxo-Propionate Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (Specify isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.