Description

Benzenepropanoic Acid, A-(Hydroxymethyl)-, (S)- is a high-purity chiral intermediate of significant importance in the synthesis of optically active pharmaceutical compounds. Its value lies in its role as a key building block for active pharmaceutical ingredients (APIs) and fine chemicals, where stereochemical purity is critical for efficacy and safety. This product is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require a reliable source of enantiomerically pure intermediates. The compound is supplied with a CAS number of 147383-72-0.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of various APIs, particularly in cardiovascular and central nervous system (CNS) drug development.
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to construct complex molecular architectures.
• Agrochemical Research: Serves as a precursor in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where specific stereochemistry is required.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry and medicinal chemistry research programs.
• Peptidomimetics: Can be incorporated into peptide analogs to modulate biological activity and stability.

Basic Information

Item	Details
Product Name	Benzenepropanoic Acid, A-(Hydroxymethyl)-, (S)-
CAS No.	147383-72-0
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(S)-3-Hydroxy-3-phenylpropanoic acid; (S)-3-Phenyl-3-hydroxypropionic acid; (S)-β-Hydroxy-β-phenylpropionic acid; (S)-HPPA; (S)-3-Hydroxy-3-phenylpropanoate; (3S)-3-Hydroxy-3-phenylpropanoic acid; L-3-Hydroxy-3-phenylpropionic acid
EINECS	Contact for details

Quality Control

Our Benzenepropanoic Acid, A-(Hydroxymethyl)-, (S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) are provided with every shipment, detailing specifications for identity, purity (HPLC), enantiomeric excess (Chiral HPLC), and related substances. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.