Description

1-Cyclopropyl-6-Fluoro-5-Methyl-7-(3-Methylpiperazin-1-Yl)-4-Oxo-Quinoline-3-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial and research importance. Its core value lies in its role as a critical building block for the synthesis of novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and API producers targeting bacterial infections.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the production of advanced fluoroquinolone antibiotic active pharmaceutical ingredients (APIs).
• Antibacterial Drug Development: Serves as a core scaffold in medicinal chemistry for designing and synthesizing new antibacterial compounds with improved potency and spectrum.
• Research & Development: Utilized in academic and industrial research settings for studying structure-activity relationships (SAR) and mechanism of action in quinolone-class drugs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex molecules with the quinoline-3-carboxylic acid pharmacophore.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antibiotic drug substances.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and regulatory testing of related pharmaceutical products.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-5-Methyl-7-(3-Methylpiperazin-1-Yl)-4-Oxo-Quinoline-3-Carboxylic Acid
CAS No.	146863-02-7
Molecular Formula	C19H22FN3O3
Molecular Weight	359.40 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 7-(3-Methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; LB20304a Intermediate; 1-Cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6-Fluoro-5-Methyl-7-(3-Methylpiperazin-1-Yl)-4-Oxo-Quinoline-3-Carboxylic Acid is manufactured under strict quality management systems. We provide material that meets exacting standards for pharmaceutical intermediate applications, with purity typically exceeding 98.0% (HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines, and we can support development toward cGMP standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.