Description

n-Cbz-9-Azabicyclo[3.3.1]nonan-3-one is a protected nitrogen-containing bicyclic ketone, serving as a sophisticated chiral building block in advanced organic synthesis. This compound is valued for its rigid, three-dimensional scaffold, which is instrumental in constructing complex molecular architectures with precise stereochemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), particularly in the areas of neurological and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Catalysis Research: Used as a precursor or ligand framework in the development of novel chiral catalysts for stereoselective reactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel bioactive compounds due to its constrained bicyclic structure.
• Peptidomimetics Development: The 9-azabicyclo[3.3.1]nonane core is a valuable scaffold for designing peptide mimics with enhanced metabolic stability.
• Academic & Industrial R&D: Serves as a high-value starting material for methodological development in organic synthesis and total synthesis projects.

Basic Information

Product Name	n-Cbz-9-Azabicyclo[3.3.1]nonan-3-one
CAS No.	146747-65-1
Molecular Formula	C16H19NO3
Molecular Weight	273.33 g/mol
Synonyms	Carbobenzoxy-9-azabicyclo[3.3.1]nonan-3-one; N-Carbobenzyloxy-9-azabicyclo[3.3.1]nonan-3-one; N-Cbz-9-azabicyclo[3.3.1]nonan-3-one; 3-Oxo-9-azabicyclo[3.3.1]nonane-9-carboxylic acid benzyl ester; Benzyl 3-oxo-9-azabicyclo[3.3.1]nonane-9-carboxylate; 9-N-Cbz-3-oxo-9-azabicyclo[3.3.1]nonane
EINECS	Contact for details

Quality Control

Our n-Cbz-9-Azabicyclo[3.3.1]nonan-3-one is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.