Description

O1-(Dimethoxytrityl)Triethylene Glycol is a specialized, high-purity chemical intermediate featuring a dimethoxytrityl (DMT) protecting group on a triethylene glycol spacer arm. This compound matters for its critical role in the controlled synthesis of complex molecules, particularly in oligonucleotide and solid-phase peptide synthesis where precise functionalization is required. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in producing advanced therapeutics, diagnostic probes, and novel biomaterials.

Application

• Oligonucleotide Synthesis: As a key building block for introducing hydrophilic spacers or linker arms during automated DNA/RNA synthesis, crucial for probe and primer manufacturing.
• Solid-Phase Peptide Synthesis (SPPS): Used to incorporate polyethylene glycol (PEG) linkers or as a handle for attaching peptides to solid supports, enhancing solubility and yield.
• Bioconjugation & Labeling Reagents: Serves as a versatile spacer in the creation of fluorescent dyes, biotin, or other reporter molecule conjugates for diagnostic assays.
• Protecting Group Chemistry: The acid-labile DMT group allows for selective deprotection in multi-step synthetic sequences, common in medicinal chemistry.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for creating specialty polymers with tailored hydrophilicity and biocompatibility.
• Antisense & siRNA Therapeutic Development: An essential intermediate in the research and production of therapeutic oligonucleotides targeting genetic diseases.

Basic Information

Product Name	O1-(Dimethoxytrityl)Triethylene Glycol
CAS No.	146669-11-6
Molecular Formula	C27H32O6
Molecular Weight	452.54 g/mol
Synonyms	1-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(4,4'-dimethoxytrityl)ethane; DMT-Triethylene Glycol; 4,4'-Dimethoxytrityltriethylene Glycol; Triethylene Glycol Monodimethoxytrityl Ether; DMT-PEG3-OH; 2-[2-[2-[(4,4'-Dimethoxytrityl)oxy]ethoxy]ethoxy]ethanol; O1-DMT-Triethylene Glycol; DMT-PEG3
EINECS	Contact for details

Quality Control

Our O1-(Dimethoxytrityl)Triethylene Glycol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates and advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.