Description

H-Trp(Boc)-Oh is a protected derivative of the essential amino acid tryptophan, widely used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over the tryptophan side chain during complex peptide assembly. It is primarily utilized in the pharmaceutical and biotechnology industries for the development of therapeutic peptides, research biochemicals, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental N-α-Boc protected amino acid for the sequential construction of peptide chains, particularly where the indole side chain of tryptophan must remain inert.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for producing custom peptides, peptide fragments, and peptide conjugates in solution.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Peptide Library Construction: A valuable component in combinatorial chemistry for generating diverse peptide libraries used in drug discovery and screening.
• Production of Protected Peptide Fragments: Used to synthesize shorter, protected peptide segments for subsequent fragment condensation strategies.

Basic Information

Product Name	H-Trp(Boc)-Oh
CAS No.	146645-63-8
Molecular Formula	C₁₆H₂₀N₂O₄
Molecular Weight	304.34 g/mol
Synonyms	N-α-tert-Butyloxycarbonyl-L-tryptophan; Boc-L-tryptophan; Boc-Trp-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; N-Boc-L-tryptophan; Boc-Tryptophan; tert-Butyloxycarbonyl-L-tryptophan; L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our H-Trp(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of peptide synthesis. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.