Description

Thp-Peg6 CAS NO 146395-14-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tetrahydropyranyl (THP) protecting group at one terminus and a hydroxyl group at the other. This compound is a critical intermediate in the synthesis of complex molecules, enabling precise control over conjugation and solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing novel therapeutics and functional polymers.

Application

• Pharmaceutical Linker: Serves as a versatile spacer and solubilizing agent in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Bioconjugation Chemistry: Used to modify peptides, proteins, and oligonucleotides, improving their pharmacokinetic properties and stability.
• Polymer Synthesis: Acts as a key monomer or initiator for creating functionalized PEG-based hydrogels, coatings, and drug delivery systems.
• Protecting Group Strategy: The THP group provides orthogonal protection for hydroxyl functions during multi-step organic synthesis, particularly in carbohydrate and natural product chemistry.
• Surface Modification: Employed to PEGylate nanoparticles and surfaces to enhance biocompatibility and reduce non-specific binding.

Basic Information

Product Name	Thp-Peg6
CAS No.	146395-14-4
Molecular Formula	C23H46O8
Molecular Weight	450.61 g/mol
Synonyms	2-[2-[2-[2-[2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; THP-PEG6-OH; Tetrahydropyranyl-PEG6-alcohol; α-THP-ω-hydroxy hexaethylene glycol; 3,6,9,12,15,18-Hexaoxahenicosan-21-ol, 2-(tetrahydro-2H-pyran-2-yloxy)-; PEG6 THP ether; Heterobifunctional PEG, THP-PEG6
EINECS	Contact for details

Quality Control

Our Thp-Peg6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.