Description

1-Boc-3-Methoxypiperidine is a protected piperidine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its primary value lies in providing a reactive amine handle protected by the acid-labile tert-butoxycarbonyl (Boc) group, enabling selective deprotection in multi-step synthetic sequences. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing piperidine-based scaffolds found in numerous therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that incorporate functionalized heterocyclic structures.
• Peptide Mimetics & PROTACs: Employed in the synthesis of peptidomimetics and Proteolysis Targeting Chimeras (PROTACs) due to its amine functionality and orthogonal protecting group.
• Ligand & Catalyst Development: Acts as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Scale-up: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	1-Boc-3-Methoxypiperidine
CAS No.	146337-23-7
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-methoxypiperidine; tert-Butyl 3-methoxypiperidine-1-carboxylate; 3-Methoxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-3-methoxypiperidine; N-Boc-3-methoxypiperidine; 1-N-Boc-3-methoxypiperidine; Piperidine, 3-methoxy-, 1-(1,1-dimethylethyl) ester; 3-Methoxypiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Methoxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.