Description

Z-Ile-Nca CAS NO 146286-84-2 is a specialized N-carboxyanhydride (NCA) derivative of the amino acid isoleucine, protected with a benzyloxycarbonyl (Z or Cbz) group. This compound serves as a critical building block for the controlled synthesis of polypeptides and advanced polymeric materials via ring-opening polymerization. It is essential for researchers and manufacturers in the pharmaceutical and biomaterials sectors who require high-purity, reactive monomers to create custom peptide sequences or biodegradable polymers with precise structural control.

Application

• Pharmaceutical Intermediate: Key monomer for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Biomaterials Research: Used in ring-opening polymerization to produce poly(isoleucine) and copolymers for drug delivery systems and tissue engineering scaffolds.
• Chemical Biology: Enables the site-specific incorporation of isoleucine residues in synthetic peptides for structure-activity relationship (SAR) studies.
• Polymer Chemistry: Serves as a reactive precursor for creating amino acid-based polymers with tailored degradation rates and mechanical properties.
• Cosmetic Peptides: A building block for synthesizing bioactive peptide sequences used in advanced skincare formulations.
• Academic & Industrial R&D: Fundamental reagent for developing new synthetic methodologies and novel functional materials.

Basic Information

Product Name	Z-Ile-Nca
CAS No.	146286-84-2
Molecular Formula	C15H17NO5
Molecular Weight	291.30 g/mol
Synonyms	N-Carboxy-DL-isoleucine anhydride, Z-protected; N-(Benzyloxycarbonyl)-DL-isoleucine N-carboxyanhydride; Z-DL-Isoleucine NCA; Cbz-Ile-NCA; (4-Methyl-2-oxo-3,6-dihydro-2H-1,3-oxazin-6-yl)acetic acid benzyl ester; Benzyl (4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl)acetate; NCA of Z-Isoleucine
EINECS	Contact for details

Quality Control

Every batch of Z-Ile-Nca is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.