Description

1-Nitro-2-(2,2,2-Trifluoroethyl)Benzene is a specialized fluorinated nitroaromatic compound that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both a nitro group and a trifluoroethyl moiety, makes it a critical intermediate for introducing fluorine-containing motifs into target molecules, which is essential for modulating their physical, chemical, and biological properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty materials and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides where the trifluoroethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with tailored electronic and surface properties.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic aromatic substitution reactions to construct complex molecular architectures.
• Fluorine Chemistry Studies: An important reagent for academic and industrial research focused on understanding the effects of fluorine substitution in organic molecules.
• Dye and Pigment Intermediate: Can be utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	1-Nitro-2-(2,2,2-Trifluoroethyl)Benzene
CAS No.	145914-06-3
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	2-(2,2,2-Trifluoroethyl)nitrobenzene; 1-Nitro-2-(trifluoroethyl)benzene; o-Nitro-α,α,α-trifluoroethylbenzene; 2-(Trifluoroethyl)nitrobenzene; Benzene, 1-nitro-2-(2,2,2-trifluoroethyl)-; α,α,α-Trifluoro-o-nitrotoluene; (2-Nitrophenyl)trifluoroethane
EINECS	Contact for details

Quality Control

Our 1-Nitro-2-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that detail specifications such as assay (by HPLC or GC), impurity profiles, and physical characteristics. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline solid or liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.