Description

Cocaethylene-D5, Drug Standard Solution is a deuterated internal standard of the cocaine metabolite cocaethylene, specifically designed for analytical and forensic applications. This high-purity reference material is essential for ensuring the accuracy, precision, and legal defensibility of quantitative analyses in complex biological matrices. It is a critical tool for toxicology laboratories, forensic science institutions, and pharmaceutical research facilities engaged in drug metabolism studies, workplace drug testing, and post-mortem investigations.

Application

• Quantitative Internal Standard for LC-MS/MS and GC-MS: Primary use as a stable isotope-labeled internal standard for the precise quantification of cocaethylene in biological samples (e.g., blood, urine, hair).
• Forensic Toxicology and Post-Mortem Analysis: Enables accurate measurement of cocaethylene concentrations for legal and medical investigations into polydrug use involving cocaine and alcohol.
• Clinical Research and Pharmacokinetics: Supports studies on the metabolism, distribution, and elimination kinetics of cocaethylene in human subjects.
• Workplace and Sports Drug Testing: Used in the development and validation of reliable screening and confirmatory methods for compliance monitoring programs.
• Method Development and Validation: Serves as a key component in establishing new analytical procedures, ensuring method robustness and meeting regulatory guidelines (e.g., SAMHSA, WADA).
• Quality Control and Proficiency Testing: Employed in laboratory QC protocols and external quality assurance schemes to maintain analytical performance and accreditation.

Basic Information

Product Name	Cocaethylene-D5, Drug Standard Solution
CAS No.	145682-86-6
Molecular Formula	C18H18D5NO4
Molecular Weight	~ 309.4 g/mol
Synonyms	Cocaethylene-d5; Benzoylecgonine ethyl ester-d5; Ethylbenzoylecgonine-d5; Cocaethylene (ethyl ester benzoylecgonine)-d5; [2β,3β]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, ethyl ester-d5; Deuterated Cocaethylene; Cocaethylene Internal Standard; EC-d5
EINECS	Contact for details

Quality Control

Every batch of Cocaethylene-D5, Drug Standard Solution is produced and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure it meets the high standards required for forensic and clinical applications, including verification of isotopic purity, chemical purity, and solution concentration. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results from techniques such as NMR, HPLC, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold chain conditions (typically 2-8°C or as specified on the label) to maintain long-term stability. Due to its highly volatile nature, ensure containers are securely sealed and handled in a well-ventilated area. For optimal shelf life, avoid repeated freeze-thaw cycles of aliquots.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (NMR / MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (MS)	≥ 98.0 atom % D
Concentration	100 µg/mL ± 5% in methanol or as specified
Solvent	Methanol (HPLC/GC Grade)
Related Substances (HPLC)	≤ 2.0% total
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.