Description

Benzyl (2S,3Ar,7As)-Octahydroindole-2-Carboxylate Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its complex, fused bicyclic structure makes it a critical precursor in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in asymmetric synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Asymmetric Synthesis: Utilized as a building block to introduce stereochemical complexity in medicinal chemistry and process R&D.
• Process Chemistry & Scale-Up: Serves as a critical raw material for the development and optimization of commercial-scale API manufacturing processes.
• Research & Development: Used in academic and industrial labs for the discovery and structure-activity relationship (SAR) studies of new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	Benzyl (2S,3Ar,7As)-Octahydroindole-2-Carboxylate Hydrochloride
CAS No.	145641-35-6
Molecular Formula	C16H22ClNO2
Molecular Weight	295.80 g/mol
Synonyms	Benzyl (2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylate Hydrochloride; (2S,3aR,7aS)-2-(Benzyloxycarbonyl)octahydroindole Hydrochloride; (2S,3aR,7aS)-Octahydroindole-2-carboxylic Acid Benzyl Ester Hydrochloride; Z-(2S,3aR,7aS)-Octahydroindole-2-carboxylate Hydrochloride; Cbz-Protected Octahydroindole-2-carboxylate HCl; (2S,3aR,7aS)-1,2,3,3a,4,5,6,7a-Octahydroindole-2-carboxylic Acid Benzyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Benzyl (2S,3Ar,7As)-Octahydroindole-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.