Description

1,1,3,3-Tetrabutylguanidine is a sterically hindered, strong organic base with the CAS number 145542-04-7. It serves as a highly effective, non-nucleophilic catalyst and reagent in demanding organic synthesis, offering superior performance over traditional amines. This compound is particularly valuable for industries requiring robust base catalysis under anhydrous conditions, such as advanced pharmaceutical manufacturing and specialty polymer production.

Application

• Pharmaceutical Synthesis: As a potent catalyst in the production of active pharmaceutical ingredients (APIs), particularly for condensation and deprotonation reactions.
• Polymer Chemistry: Catalyst for the production of polyurethanes, polycarbonates, and other specialty polymers where controlled polymerization is critical.
• Fine Chemical Manufacturing: Key reagent in the synthesis of complex organic molecules, including dyes, pigments, and agrochemical intermediates.
• Asymmetric Synthesis: Used as a chiral base or as a component in catalyst systems for enantioselective transformations.
• Gas Treating/Separation: Potential application as a non-aqueous absorbent for acid gases like carbon dioxide (CO₂) and hydrogen sulfide (H₂S).
• Cross-Coupling Reactions: Facilitates palladium-catalyzed reactions such as Suzuki and Heck couplings by acting as a stoichiometric base.

Basic Information

Product Name	1,1,3,3-Tetrabutylguanidine
CAS No.	145542-04-7
Molecular Formula	C₁₇H₃₇N₃
Molecular Weight	283.50 g/mol
Synonyms	Tetrabutylguanidine; TBG; 1,1,3,3-Tetrabutylguanidine; N,N,N',N'-Tetrabutylguanidine; Guanidine, N,N,N',N'-tetrabutyl-; 1,1,3,3-Tetra-n-butylguanidine; NSC 403819; UNII-2F6F9Q8K4P
EINECS	Contact for details

Quality Control

Our 1,1,3,3-Tetrabutylguanidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration, identity confirmation by FT-IR, and impurity profiling, to ensure it meets stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 0.5 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.