Description

Capromab Pendetide is a diagnostic radiopharmaceutical agent, specifically a murine monoclonal antibody (7E11-C5.3) conjugated to the linker-chelator GYK-DTPA. This compound is critical for the targeted imaging of prostate-specific membrane antigen (PSMA), a glycoprotein expressed on the surface of prostate cancer cells. It is primarily utilized in clinical and research settings for the detection, staging, and monitoring of prostate carcinoma. The product, identified by CAS NO 145464-28-4, is supplied as a high-purity reagent for professional use.

Application

• Diagnostic Imaging Agent: Used as the active pharmaceutical ingredient (API) in the preparation of Indium-111 (111In) capromab pendetide (ProstaScint®) for immunoscintigraphy.
• Prostate Cancer Detection: Aids in the detection of extraprostatic, soft-tissue metastases in patients with clinically localized prostate cancer prior to initial therapy.
• Cancer Staging and Monitoring: Employed for post-prostatectomy evaluation to assess the extent of disease and monitor for recurrence in patients with a rising prostate-specific antigen (PSA) level.
• Biomedical Research: Serves as a key reagent in oncology research for studying PSMA expression, tumor biology, and the development of targeted cancer therapies.
• Radiopharmaceutical Development: Used as a reference standard and precursor in the development and quality control of novel PSMA-targeting diagnostic and therapeutic agents.

Basic Information

Product Name	Capromab Pendetide
CAS No.	145464-28-4
Molecular Formula	C~2600H~4000N~700O~800S~50 • (C14H22N3O10)~1
Molecular Weight	~150,000 g/mol (Antibody conjugate)
Synonyms	7E11-C5.3-GYK-DTPA; Indium In 111 Capromab Pendetide Precursor; Monoclonal Antibody 7E11-C5.3, anti-(prostate carcinoma cell) (human-mouse monoclonal 7E11-C5.3 γ1-chain), disulfide with human-mouse monoclonal 7E11-C5.3 κ-chain, dimer, conjugate with N-[2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]ethyl]-N-(4-isothiocyanatobenzyl)glycine; ProstaScint Kit Component; CYT-356; GYK-DTPA-CYT-356
EINECS	Contact for details

Quality Control

Our Capromab Pendetide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, potency, and consistency. Specifications are aligned with pharmaceutical-grade standards for diagnostic agent precursors. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for critical parameters including assay, immunoreactivity, endotoxin levels, and sterility (where applicable).

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term storage, maintain at -70°C or under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Immunoreactivity	≥ 70% (Specific binding to PSMA-expressing cells)
Protein Content (UV)	Reported on COA
Endotoxin	< 10 EU/mg
Moisture Content (KF)	< 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.