Description

6,8-Difluoroquinoline is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of novel drug candidates, particularly in antimicrobial and anticancer research.
• Agrochemical Development: Used in creating advanced active ingredients for crop protection products, leveraging fluorine's properties to enhance efficacy and environmental profile.
• Material Science Research: Serves as a building block for organic electronic materials, such as ligands for OLEDs and other fluorinated polymers.
• Chemical Synthesis: Acts as a versatile substrate for further functionalization via cross-coupling, nucleophilic substitution, and other metal-catalyzed reactions.
• Ligand and Catalyst Design: Employed in the development of novel chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A standard compound for investigating structure-activity relationships (SAR) in fluorinated quinoline systems.

Basic Information

Product Name	6,8-Difluoroquinoline
CAS No.	145241-75-4
Molecular Formula	C9H5F2N
Molecular Weight	165.14 g/mol
Synonyms	6,8-Difluoroquinoline; Quinoline, 6,8-difluoro-; 6,8-Difluoro-quinoline; 145241-75-4; 2,4-Difluoroquinoline; 6,8-Difluorochinolin; 6,8-Difluoro-1-azanaphthalene
EINECS	Contact for details

Quality Control

Our 6,8-Difluoroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.