Description

(S)-1-Bromo-4-(Methylsulfinyl)Benzene is a high-purity chiral building block featuring a bromine atom and a methylsulfinyl group in para-substitution on a benzene ring. This compound is a valuable intermediate in asymmetric synthesis, particularly for the construction of complex molecules in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Ligand Precursor: Used in the preparation of chiral sulfoxide-containing ligands for asymmetric catalysis, including cross-coupling and oxidation reactions.
• Agrochemical Research: Serves as a building block for developing new chiral active ingredients with improved efficacy and environmental profiles.
• Material Science: Employed in the synthesis of advanced organic electronic materials and liquid crystals, where the sulfinyl group can influence molecular packing and electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for Suzuki, Negishi, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Asymmetric Synthesis: Utilized in stereoselective transformations, leveraging the chiral sulfinyl group as a temporary chiral auxiliary or directing group.

Basic Information

Product Name	(S)-1-Bromo-4-(Methylsulfinyl)Benzene
CAS No.	145166-15-0
Molecular Formula	C7H7BrOS
Molecular Weight	219.10 g/mol
Synonyms	(S)-4-Bromophenyl Methyl Sulfoxide; (S)-p-Bromophenyl Methyl Sulfoxide; (S)-1-Bromo-4-(Methylsulfinyl)Benzene; (S)-Methyl 4-Bromophenyl Sulfoxide; (S)-4-Bromobenzenesulfinylmethane; (S)-Bromo(4-methylsulfinyl)benzene; (S)-Bromophenyl methyl sulfoxide
EINECS	Contact for details

Quality Control

Our (S)-1-Bromo-4-(Methylsulfinyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.