Description

tert-Butyl-L-Pipecolic Acid Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in organic synthesis. Its value lies in providing a rigid, sterically hindered pipecolic acid scaffold, which is crucial for modulating the pharmacokinetic and pharmacodynamic properties of bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly for the synthesis of peptide mimetics, protease inhibitors, and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, especially in oncology and neurology.
• Peptidomimetic Chemistry: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Protease Inhibitor Design: Serves as a core scaffold for designing inhibitors of various enzymes like HCV NS3/4A protease and DPP-4.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel bioactive compound libraries.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or resolving agent in stereoselective synthetic routes.
• API Development: Incorporated into the final structure of advanced pharmaceutical ingredients requiring specific stereochemistry.

Basic Information

Product Name	tert-Butyl-L-Pipecolic Acid Hydrochloride
CAS No.	145064-67-1
Molecular Formula	C10H20ClNO2
Molecular Weight	221.72 g/mol
Synonyms	(2S)-1-(tert-Butoxycarbonyl)piperidine-2-carboxylic acid hydrochloride; L-Pipecolic acid, N-Boc-, hydrochloride; Boc-L-Pipecolic acid HCl; N-Boc-L-Pipecolic Acid Hydrochloride; (S)-1-(tert-Butoxycarbonyl)piperidine-2-carboxylic acid hydrochloride; tert-Butoxycarbonyl-L-pipecolic acid hydrochloride; N-tert-Butoxycarbonyl-L-pipecolic acid hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl-L-Pipecolic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D. Standard testing includes HPLC for assay and chiral purity, along with identity confirmation (IR, NMR) and residual solvent analysis. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.