Description

n-Boc-1,3-Diamino-2-propanol is a versatile bifunctional building block featuring both a primary amine and a secondary alcohol, each protected for selective deprotection. This compound is critical for the synthesis of complex molecules where precise control over functional group reactivity is required. It is primarily utilized by pharmaceutical and fine chemical research organizations for developing active pharmaceutical ingredients (APIs), peptide mimetics, and specialized linkers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring chiral diamine or amino alcohol scaffolds.
• Peptide Chemistry: Used to introduce protected amino alcohol spacers or as a building block for non-natural amino acids and peptide backbone modifications.
• Linker Synthesis: Serves as a foundational unit for constructing cleavable or functionalized linkers used in bioconjugation and prodrug development.
• Ligand and Catalyst Preparation: Employed in the preparation of chiral ligands for asymmetric catalysis and metal-chelating agents.
• Polymer Science: Acts as a monomer or chain extender for synthesizing specialized polyamides, polyurethanes, or functional polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tools for studying biological processes.

Basic Information

Product Name	n-Boc-1,3-Diamino-2-propanol
CAS No.	144912-84-5
Molecular Formula	C8H18N2O3
Molecular Weight	190.24 g/mol
Synonyms	1,3-Diamino-2-propanol, N-Boc derivative; tert-Butyl N-[3-amino-2-hydroxypropyl]carbamate; 2-Propanol, 1,3-diamino-, 1-(1,1-dimethylethoxy)carbonyl derivative; 1-(tert-Butoxycarbonylamino)-3-amino-2-propanol; 3-Amino-2-hydroxypropylcarbamic acid tert-butyl ester; Boc-DAP-OH; N-Boc-1,3-diaminopropan-2-ol; (3-Amino-2-hydroxypropyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-1,3-Diamino-2-propanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.