Description

Reveromycin B CAS NO 144860-68-4 is a specialized ansamycin-type polyketide antibiotic isolated from *Streptomyces* species. This compound is of significant interest in biochemical and pharmacological research due to its potent and selective inhibitory activity against eukaryotic cells, particularly its ability to induce apoptosis in osteoclasts. It serves as a critical research tool for scientists and developers in the life sciences sector, enabling advanced studies in bone biology, cancer research, and the development of novel therapeutic agents.

Application

• Biomedical Research: Used as a selective inhibitor to study osteoclast function, bone resorption mechanisms, and related metabolic bone diseases.
• Anticancer Agent Development: Investigated for its apoptosis-inducing properties in various cancer cell lines, serving as a lead compound in oncology research.
• Cell Biology Studies: Employed as a biochemical tool to probe cytoskeletal dynamics and cell adhesion processes due to its specific effects on eukaryotic cells.
• Pharmacology & Toxicology: Utilized in mode-of-action studies and safety assessments to understand the cellular pathways affected by ansamycin antibiotics.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on microbiology, natural product chemistry, and signal transduction.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Reveromycin B
CAS No.	144860-68-4
Molecular Formula	C₃₇H₅₈O₁₂
Molecular Weight	706.86 g/mol
Synonyms	Reveromycin B; Antibiotic MM 46115; MM 46115; Reveromycin B, Antibiotic; Reveromycin B (MM 46115); (3S,4R,5S,6R,8R,10R,11S,12S,13S,14E,16E,18E,20S,21R,24R)-20-[(2S,3S,4S,5S)-3,4-Dihydroxy-2,4,5-trimethyl-1-oxoheptyl]-5,6,8,10,11,12,13,21,24-nonahydroxy-3,11,16,18,22-pentamethyl-4,9-dioxo-1-oxacyclotetracosa-14,16,18-trien-23-one
EINECS	Contact for details

Quality Control

Our Reveromycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) containing purity, identity confirmation, and impurity profile is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere after each use to maintain stability and prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.