Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-8-(Trifluoromethyl)- is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and development. This molecule serves as a critical pharmaceutical intermediate in the synthesis of novel antibacterial agents, particularly fluoroquinolone antibiotics. It is essential for R&D chemists and process development scientists working in the active pharmaceutical ingredient (API) sector who require reliable, high-quality building blocks for complex syntheses.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a core scaffold in the research and synthesis of next-generation broad-spectrum antibacterial agents.
• Pharmaceutical R&D: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs) at pilot and commercial scales.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Custom Synthesis: Acts as a starting material or advanced intermediate for the custom synthesis of proprietary compounds and novel chemical entities.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-8-(Trifluoromethyl)-
CAS No.	144633-80-7
Molecular Formula	C19H19F4N3O3
Molecular Weight	413.37 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-8-(trifluoromethyl)-3-quinolinecarboxylic acid; 8-Trifluoromethyl-Sparfloxacin Intermediate; 8-CF3-Sparfloxacin Precursor; 1-Cyclopropyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic Acid; Sparfloxacin Derivative; Fluoroquinolone Intermediate 144633-80-7; Antibacterial Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with cGMP guidelines where applicable for API starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.