Description

Amino-PEG4-(CH2)3CO2H is a heterobifunctional polyethylene glycol (PEG) linker featuring a primary amine and a carboxylic acid group, separated by a flexible PEG spacer and a short alkyl chain. This compound is a critical building block for bioconjugation and cross-linking applications, enabling the stable and site-specific attachment of biomolecules, drugs, or labels. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries who require reliable, high-purity linkers for developing advanced therapeutics and research tools.

Application

• Bioconjugation Reagent: For coupling peptides, proteins, antibodies, or oligonucleotides to surfaces, nanoparticles, or other biomolecules via its amine and carboxyl reactive ends.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation Chemistry: Used to modify therapeutic proteins and peptides to enhance their stability, reduce immunogenicity, and prolong circulation half-life.
• Cross-linking Agent: Facilitates the formation of stable amide bonds between different molecules in material science and hydrogel formation.
• Diagnostic Probe Synthesis: Employed in the construction of fluorescent probes, MRI contrast agents, and other imaging reagents.
• Drug Delivery System Fabrication: Incorporated into micelles, liposomes, and polymer-drug conjugates as a functional spacer.
• Surface Functionalization: Used to create amine- or carboxyl-terminated self-assembled monolayers (SAMs) on gold, silica, or other substrates for biosensor applications.
• Biomaterial Modification: Imparts hydrophilicity and biocompatibility to scaffolds and implants for tissue engineering.

Basic Information

Product Name	Amino-PEG4-(CH2)3CO2H
CAS No.	144598-03-8
Molecular Formula	C15H31NO7
Molecular Weight	337.41 g/mol
Synonyms	15-Amino-4,7,10,13-tetraoxapentadecanoic Acid; 3,6,9,12-Tetraoxapentadecanedioic acid 15-amide; Amino-PEG4-propionic acid; NH2-PEG4-CH2CH2CH2-COOH; 4,7,10,13-Tetraoxa-1-azapentadecan-15-oic acid; 3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid; PEG4-Amine-Acid; Heterobifunctional PEG linker, Amine-PEG4-Acid
EINECS	Contact for details

Quality Control

Our Amino-PEG4-(CH2)3CO2H is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere or desiccant to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.