Description

1,2,3,5-Tetra-o-Acetyl-β-L-Ribofuranose is a key acetylated ribose derivative and a vital protected intermediate in nucleoside chemistry. Its primary value lies in enabling the controlled synthesis of complex molecules by providing a reactive sugar scaffold with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of antiviral agents, nucleoside analogs, and other therapeutic oligonucleotides. The CAS number for this material is 144490-03-9.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleoside-based antiviral drugs (e.g., for HIV, Hepatitis) and anticancer agents.
• Oligonucleotide Synthesis: Serves as a protected precursor for the solid-phase or solution-phase synthesis of RNA and modified DNA strands.
• Carbohydrate Chemistry Research: Used in academic and industrial R&D for studying glycosylation reactions and synthesizing complex sugar molecules.
• Prodrug Development: Employed to create prodrug forms of nucleoside analogs to improve bioavailability and pharmacokinetic properties.
• Bioconjugation: Acts as a linker or spacer molecule for attaching sugars to proteins, peptides, or other biomolecules.
• Diagnostic Reagent Manufacturing: Used in the production of labeled nucleotides and probes for molecular diagnostics and sequencing.

Basic Information

Item	Details
Product Name	1,2,3,5-Tetra-o-Acetyl-β-L-Ribofuranose
CAS No.	144490-03-9
Molecular Formula	C13H18O9
Molecular Weight	318.28 g/mol
Synonyms	1,2,3,5-Tetra-O-acetyl-β-L-ribofuranose; β-L-Ribofuranose, 1,2,3,5-tetraacetate; 1,2,3,5-Tetra-O-acetyl-L-ribofuranose; Tetraacetyl-L-ribofuranose; L-(–)-1,2,3,5-Tetra-O-acetylribofuranose; 1,2,3,5-Tetraacetyl-β-L-ribofuranose; Acetylated L-ribose
EINECS	Contact for details

Quality Control

Our 1,2,3,5-Tetra-o-Acetyl-β-L-Ribofuranose is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-18.0° to -22.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.