Description

Z-Asn(Mtt)-OH is a protected asparagine derivative, specifically featuring the 4-methyltrityl (Mtt) protecting group on the side-chain amide nitrogen. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, selectively protected amino acids for the development of peptide-based therapeutics and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the orthogonal deprotection of the side chain.
• Peptide Drug Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for peptide hormones, antibiotics, and other therapeutic peptides.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries for drug discovery and screening.
• Bioconjugation & Labeling: The selectively protected side chain allows for site-specific modifications and the introduction of labels or linkers.
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships and developing novel biomaterials.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Item	Detail
Product Name	Z-Asn(Mtt)-OH
CAS No.	144317-18-0
Molecular Formula	C33H31NO5
Molecular Weight	521.60 g/mol
Synonyms	Nα-Carbobenzoxy-Nβ-(4-methyltrityl)-L-asparagine; Z-L-Asparagine(Mtt)-OH; Nα-Cbz-Nβ-(4-methyltrityl)-L-asparagine; Cbz-Asn(Mtt)-OH; Nα-Z-Nβ-(4-methyltrityl)-L-asparagine; Fmoc-Asn(Mtt)-OH precursor; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[[[4-(triphenylmethyl)phenyl]methyl]amino]-3-oxopropanoic acid
EINECS	Contact for details

Quality Control

Our Z-Asn(Mtt)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.