Description

6-Azaspiro[2.5]Octane,1,1-Difluoro-(9Ci) is a specialized spirocyclic building block containing a difluoromethylene group and a nitrogen atom within a constrained bicyclic framework. This unique structure makes it a valuable intermediate for medicinal chemistry and agrochemical research, enabling the modulation of physicochemical properties and metabolic stability in target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the spirocyclic and fluorine motifs can enhance bioactivity.
• Chemical Biology Probes: Serves as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential intermediate for advanced polymers or ligands with specific steric and electronic properties.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and the study of fluorine's effects in molecular design.

Basic Information

Product Name	6-Azaspiro[2.5]Octane,1,1-Difluoro-(9Ci)
CAS No.	144230-47-7
Molecular Formula	C7H11F2N
Molecular Weight	147.16 g/mol
Synonyms	1,1-Difluoro-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane, 1,1-difluoro-; 1,1-Difluoro-6-azaspiro[2.5]octane (9CI); 6-Azaspiro[2.5]octane,1,1-difluoro-; 144230-47-7; 1,1-Difluoro-6-azaspiro[2.5]octane hydrochloride; Difluoroazaspirooctane
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[2.5]Octane,1,1-Difluoro-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong acids. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.