Description

2,8-Diazaspiro[5.5]Undecane-1,7-Dione, 2-(Phenylmethyl)- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 143806-82-0. This compound is valued for its complex spirocyclic structure, which serves as a critical building block in modern medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing spirocyclic compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Serves as a core structural element in the development of new Active Pharmaceutical Ingredients (APIs) requiring specific three-dimensional geometry.
• Organic Synthesis Building Block: Employed in advanced organic synthesis for constructing complex heterocyclic systems due to its rigid, bicyclic framework.
• Contract Research & Manufacturing (CRAM): Supplied to CRAM organizations supporting pharmaceutical clients from preclinical to commercial manufacturing stages.

Basic Information

Product Name	2,8-Diazaspiro[5.5]Undecane-1,7-Dione, 2-(Phenylmethyl)-
CAS No.	143806-82-0
Molecular Formula	C16H20N2O2
Molecular Weight	272.34 g/mol
Synonyms	2-Benzyl-2,8-diazaspiro[5.5]undecane-1,7-dione; 2-Benzyl-2,8-diazaspiro[5.5]undecane-1,7-dione; 2-(Phenylmethyl)-2,8-diazaspiro[5.5]undecane-1,7-dione; 2,8-Diazaspiro[5.5]undecane-1,7-dione, 2-(phenylmethyl)-; 143806-82-0; 2-Benzyl-2,8-diazaspiro[5.5]undecane-1,7-dione; 2-(Phenylmethyl)-2,8-diazaspiro[5.5]undecane-1,7-dione
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[5.5]Undecane-1,7-Dione, 2-(Phenylmethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.