Description

3-Trimethylsilylbenzylguanidine is a specialized organosilicon guanidine derivative, a key building block in advanced organic synthesis. This compound matters for its unique reactivity profile, combining the protective and directing properties of a trimethylsilyl group with the potent nucleophilicity and basicity of a benzylguanidine moiety. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex nitrogen-containing heterocycles and as a precursor for novel catalysts and ligands.

Application

• Pharmaceutical Intermediate: A versatile synthon for the synthesis of novel guanidine-based drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in developing new classes of herbicides and fungicides that leverage the bioactivity of the guanidine functional group.
• Catalyst & Ligand Precursor: Serves as a starting material for creating sophisticated organocatalysts and metal-chelating ligands for asymmetric synthesis.
• Material Science: Employed in the surface modification of silica and other materials, where the silyl group facilitates attachment.
• Chemical Biology Probe Development: Useful for labeling and studying biological systems that interact with guanidinium ions, such as ion channels and transporters.
• Polymer Additive: Investigated as a potential curing agent or cross-linking modifier in specialty polymer formulations.

Basic Information

Product Name	3-Trimethylsilylbenzylguanidine
CAS No.	143773-92-6
Molecular Formula	C11H19N3Si
Molecular Weight	221.38 g/mol
Synonyms	N-(3-Trimethylsilylbenzyl)guanidine; 1-(3-Trimethylsilylbenzyl)guanidine; Guanidine, N-[(3-trimethylsilyl)phenyl]methyl]-; Benzylguanidine, 3-trimethylsilyl-; TMS-Benzylguanidine; 3-(Trimethylsilyl)benzylguanidine
EINECS	Contact for details

Quality Control

Our 3-Trimethylsilylbenzylguanidine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.