Description

5-(2'-Fluoroethyl)Flumazenil is a high-purity, fluorinated derivative of the benzodiazepine receptor antagonist flumazenil. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development, particularly for studying the GABAA receptor complex. It is essential for researchers and manufacturers in the neuropharmacology and medicinal chemistry sectors who require precise, high-quality building blocks for developing diagnostic tools and novel therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel benzodiazepine receptor ligands and positron emission tomography (PET) radiotracers.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing and research laboratories.
• Neuroscience Research: A vital tool for in vitro and ex vivo binding studies to investigate the pharmacology and distribution of GABAA receptor subtypes.
• Metabolite Studies: Employed in the identification and quantification of metabolites in pharmacokinetic and toxicological research related to flumazenil analogs.
• Chemical Biology: Serves as a probe compound for studying receptor-ligand interactions and signal transduction pathways.

Basic Information

Product Name	5-(2'-Fluoroethyl)Flumazenil
CAS No.	143693-57-6
Molecular Formula	C17H15FN4O3
Molecular Weight	342.33 g/mol
Synonyms	5-(2-Fluoroethyl)flumazenil; 8-Fluoro-5,6-dihydro-5-(2-fluoroethyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester; Ethyl 8-fluoro-5,6-dihydro-5-(2-fluoroethyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Ro 15-4513 5-(2-Fluoroethyl) analog; 5-(2-Fluoroethyl)-8-fluoro-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 5-(2'-Fluoroethyl)Flumazenil is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.