Description

4-(4-n-Maleimidophenyl)Butyric Acid Hydrazide is a heterobifunctional crosslinking agent featuring both a maleimide group and a hydrazide moiety. This compound is critical for creating stable, site-specific conjugations between biomolecules, such as antibodies and enzymes, or for attaching payloads to targeting vectors. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and diagnostic reagent industries for developing advanced therapeutic and analytical platforms.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via the hydrazide group.
• Protein/Peptide Labeling: Covalent attachment of fluorophores, enzymes, or other probes to proteins for imaging and detection assays.
• Surface Functionalization: Modification of sensor chips, nanoparticles, or solid supports for biosensor and diagnostic device manufacturing.
• Polymer Chemistry: Synthesis of functionalized polymers and hydrogels with reactive handles for further bioconjugation.
• Carbohydrate Conjugation: Linking sugars or glycoproteins to carrier proteins or surfaces for vaccine and glycobiology research.
• Crosslinking Studies: Investigation of protein-protein interactions and complex structures in structural biology.

Basic Information

Product Name	4-(4-n-Maleimidophenyl)Butyric Acid Hydrazide
CAS No.	143379-89-9
Molecular Formula	C14H15N3O3
Molecular Weight	273.29 g/mol
Synonyms	4-(4-Maleimidophenyl)butyric acid hydrazide; 4-(p-Maleimidophenyl)butyric hydrazide; 4-(4-Maleimidophenyl)butyric hydrazide; 4-(4-Maleimidophenyl)butyric acid hydrazide; MPBH; 4-(4-Maleimidophenyl)butyryl hydrazide; 4-(4-Maleimidophenyl)butanoic acid hydrazide; 4-(4-Maleimidophenyl)butyric acid, hydrazide
EINECS	Contact for details

Quality Control

Our 4-(4-n-Maleimidophenyl)Butyric Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.