Description

1,3-Dioxane, 2-Ethynyl-4-Methyl-, (2R-Cis)- (9Ci) is a specialized chiral heterocyclic compound featuring a dioxane ring fused with an ethynyl group. This unique structure makes it a valuable high-purity building block and key chiral intermediate for advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of complex, optically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to induce stereoselectivity in complex molecule construction.
• Fine Chemical Production: Employed in the synthesis of specialty chemicals, agrochemicals, and advanced materials where specific stereochemistry is required.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new reaction pathways involving acetylenic and heterocyclic systems.
• Ligand and Catalyst Development: Potential use in the design of novel chiral ligands and organocatalysts for enantioselective transformations.

Basic Information

Product Name	1,3-Dioxane, 2-Ethynyl-4-Methyl-, (2R-Cis)- (9Ci)
CAS No.	143136-91-8
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	(2R,4S)-2-Ethynyl-4-methyl-1,3-dioxane; (2R-cis)-2-Ethynyl-4-methyl-1,3-dioxane; 4-Methyl-2-ethynyl-1,3-dioxane, (2R-cis)-; cis-2-Ethynyl-4-methyl-1,3-dioxane; 2-Ethynyl-4-methyl-1,3-dioxane, (2R,4S)-; Chiral 2-ethynyl-1,3-dioxane derivative; (2R,4S)-4-Methyl-2-ethynyl-1,3-dioxane
EINECS	Contact for details

Quality Control

Our production of 1,3-Dioxane, 2-Ethynyl-4-Methyl-, (2R-Cis)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC analysis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request. We support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be amber or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.