Description

(1R,2R)-2-Fluorocyclopropanamine Hydrochloride is a high-purity, chiral fluorinated building block essential for advanced pharmaceutical synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic diseases. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the production of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and enzyme modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and cyclopropane geometry on bioactivity.
• Agrochemical Development: Serves as a building block for novel, enantiomerically pure pesticides and herbicides.
• Ligand Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability.
• Diagnostic Agent Precursor: Potential intermediate in the synthesis of fluorinated compounds for Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	(1R,2R)-2-Fluorocyclopropanamine Hydrochloride
CAS No.	143062-85-5
Molecular Formula	C3H7ClFN
Molecular Weight	111.55 g/mol
Synonyms	(1R,2R)-2-Fluorocyclopropylamine Hydrochloride; (1R,2R)-2-Fluorocyclopropan-1-amine Hydrochloride; trans-2-Fluorocyclopropanamine Hydrochloride; (1R,2R)-2-Fluoro-1-aminocyclopropane Hydrochloride; (1R,2R)-1-Amino-2-fluorocyclopropane Hydrochloride; 2-Fluorocyclopropanamine Hydrochloride, (1R,2R)-; (1R,2R)-2-Fluorocyclopropylammonium Chloride
EINECS	Contact for details

Quality Control

Our (1R,2R)-2-Fluorocyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.