Description

2-Fluoro-5-Nitrobenzyl Chloride is a versatile and reactive halogenated aromatic building block essential for advanced organic synthesis. Its bifunctional nature, featuring both a reactive benzyl chloride group and an electron-withdrawing nitro substituent, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as the synthesis of active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its aromatic halogen for further functionalization.
• Peptide & Protein Research: Acts as a reagent for the selective modification of amino acids or for introducing protective groups in solid-phase peptide synthesis (SPPS).
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and functionalized surfaces.
• Ligand & Catalyst Development: Employed in the creation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Dye & Pigment Manufacturing: Intermediate for synthesizing nitro- and fluoro-substituted colorants with specific light-fastness and hue properties.

Basic Information

Product Name	2-Fluoro-5-Nitrobenzyl Chloride
CAS No.	143032-52-4
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-(Chloromethyl)-2-fluoro-5-nitrobenzene; (2-Fluoro-5-nitrophenyl)methyl chloride; 2-Fluoro-5-nitrobenzylchloride; 2-Fluoro-5-nitrobenzyl chloride; 5-Nitro-2-fluorobenzyl chloride; α-Chloro-2-fluoro-5-nitrotoluene; Benzene, 1-(chloromethyl)-2-fluoro-5-nitro-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitrobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.