Description

(3-Exo)-3-Amino-8-(Phenylmethyl)-8-Azabicyclo[3.2.1]Octane-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a complex bicyclic structure. This compound matters for its role as a critical building block in the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and neurological research. Pharmaceutical manufacturers and advanced R&D laboratories need this high-value intermediate to develop new therapeutic agents with precision and reliability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for neurological targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural motif in the research and production of novel APIs.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Asymmetric Synthesis: Leverages its rigid, three-dimensional exo-amine structure for stereoselective chemical transformations.
• Biochemical Research: Employed as a ligand or probe in studying enzyme inhibition and receptor binding mechanisms.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations for cGMP-compliant production runs.

Basic Information

Product Name	(3-Exo)-3-Amino-8-(Phenylmethyl)-8-Azabicyclo[3.2.1]Octane-3-Carbonitrile
CAS No.	142838-94-6
Molecular Formula	C15H19N3
Molecular Weight	241.33 g/mol
Synonyms	8-Benzyl-3-amino-8-azabicyclo[3.2.1]octane-3-carbonitrile (exo-); 3-Amino-8-benzyl-8-azabicyclo[3.2.1]octane-3-carbonitrile; (exo)-3-Amino-8-benzyl-8-azabicyclo[3.2.1]octane-3-carbonitrile; 8-Azabicyclo[3.2.1]octane-3-carbonitrile, 3-amino-8-(phenylmethyl)-, (3-exo)-; Troparil intermediate; Bicyclic tropane derivative; 142838-94-6; exo-3-Amino-8-benzyl-8-azabicyclo[3.2.1]octane-3-carbonitrile
EINECS	Contact for details

Quality Control

Our (3-Exo)-3-Amino-8-(Phenylmethyl)-8-Azabicyclo[3.2.1]Octane-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged exposure to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (exo-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.